• Prospective trial with 43 wrists (32 patients) previously diagnosed with carpal tunnel syndrome and 5 wrists in normal volunteers. Hyperintensity of the median nerve occurred in 95% of the wrists previously diagnosed with CTS and in 0% of the normals. Other measures were less reliably correlated with the presence of the diagnosis or of the outcome. Good surgical outcome occurred in 74% of patients diagnosed previously with CTS using traditional methods, but good surgical outcome occurred in 83% of patients with abnormal Neurography. Use of Neurography to diagnose carpal tunnel syndrome predicts good surgical outcome more effectively than traditional methods.

• Prospective trial with 31 elbows (27 patients) with physical exam and history suggestive of cubital tunnel syndrome and 10 asymptomatic volunteers. Hyperintensity of the ulnar nerve at the elbow was found in 97% and swelling of the nerve in 74%. None of the normal volunteers had either hyperintensity or swelling of the ulnar nerve. Patients with one or two abnormal MR findings had electrodiagnostic tests and these tests were positive in only 68% of the patients. Using the MR results rather than the electrodiagnostic results as the surgical indication, there was 100% good or excellent outcome from surgery.

• A prospective trial with 120 patients demonstrated that image findings were very reliable across multiple readers. It was possible to identify image findings which correlated well with the presence of clinical symptoms. When compared to the very reliable traditional reference standard technique of electrodiagnostic tests for carpal tunnel syndrome, however, there was no gain in diagnostic efficiency.
  

Six year formal outcome study for 239 patients with sciatica in which the cause could not be diagnosed by routine methods or in whom the original diagnosis and treatment proved to be incorrect (e.g. failed spine surgery). This Class A prospective clinical efficacy study in a large homogenous group of patients with a common condition showed that MR Neurography had a 93% specificity for correct diagnosis resulting good to excellent outcome after treatment in more than 80% of these patients.